Can I mix?Reviewed: Jan 11, 2026~1 min

Can I Mix Alcohol and Antidepressants? Effects of Combining Moderate Wine Intake While on SSRIs During a Social Gathering

Short answer

⚠️Depends / use caution

It depends. Moderate wine intake with SSRIs may increase drowsiness, affect coordination, and could reduce the medication's effectiveness, but individual reactions vary.

Why people ask this

People often wonder if it's safe to enjoy wine during social events while on SSRIs, concerned about possible risks, side effects, and interactions with their medication.

When it might be safe

Some adults may tolerate low alcohol intake on SSRIs without obvious side effects
Spacing drinks out over several hours with food may reduce risk
Consulting a healthcare provider for personalized advice

When it is not safe

Increased sedation or sleepiness
Impaired judgment, even with moderate alcohol
Some SSRIs can interact unpredictably with alcohol

Possible risks

Higher chance of feeling dizzy or unsteady
Worsened symptoms of anxiety or depression afterwards
Potential for reduced efficacy of antidepressants

Safer alternatives

Opt for non-alcoholic wine or mocktails
Limit to one glass and drink water between sips
Socialize without drinking and focus on conversation

Bottom line

Mixing moderate wine with SSRIs at a social gathering may be tolerated by some, but it increases risks of drowsiness, impaired coordination, and reduced medication effectiveness. Always check with your doctor before combining alcohol with antidepressants.

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